abortion | spontaneous or induced expulsion of the embryo or fetus from uterus. |
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aneuploidy | Having one extra or one less chromosome to the parental number.
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autosome | Any chromosome that is the same in males and females of the species.
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crossing over | an interaction in which non-sister chromatids of a pair of homologous chromosomes break at corresponding sites and exchange segments.
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deletion | At cytological level, loss of a segment from a chromosome.
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disease | Outcome of infection mobilized fast enough and a pathogen's activities interfere with normal body functions.
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double-blind study | investigators independently collect, then compare data.
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duplication | Gene sequence repeated several to many hundreds or thousands of times. Even normal chromosomes have such sequences.
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genetic abnormality | A rare or less common version of a heritable trait.
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genetic disorder | Any inherited condition that causes mild to severe medical problems.
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genetic recombination | any process that puts new genetic information into a DNA molecule.
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homologous chromosome | Of cells with a diploid chromosome number, one of a pair of chromosomes identical in size, shape, and gene sequence. Nonidentical sex chromosomes (e.g., X and Y) also interact as homologues during meiosis.
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in-vitro fertilization | Conception outside the body (''in glass'' petri dishes or test tubes).
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independent assortment | each pair of homologous chromosomes are sorted before shipment to gametes independently of how the other pairs were sorted. Later modified to account for the disruptive effect of crossing over on linkages.
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inversion | Part of a chromosome that became oriented in reverse, with no molecular loss.
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karyotype | Preparation of metaphase chromosomes sorted by length, centromere location, other defining features.
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linkage group | All genes on a chromosome.
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mosaicism | Cells of same type express genes differently, so phenotypic differences emerge in same type of tissue. E.g., occurs by X chromosome inactivation in female mammals.
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Non-disjunction | Failure of sister chromatids or a pair of homologous chromosomes to separate during meiosis or mitosis.
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polyploidy | Having three or more of each type of chromosome in the nucleus of a eukaryotic cell at interphase.
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reciprocal cross | A paired cross. In the first cross, one parent displays the trait of interest , the other parent displays it.
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sex chromosome | A chromosome with genes that affect sexual traits. Depending on the species, somatic cells have one or two sex chromosomes of the same or different type (e.g., in mammals, XX females, XY males).
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syndrome | A set of symptoms that may not individually be a telling clue but collectively , a genetic disorder or disease.
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translocation | movement of a stretch of DNA to a new chromosomal location with no molecular loss. Of vascular plants, distribution of organic compounds by way of phloem.
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X chromosome | A type of sex chromosome. An XX mammalian embryo becomes female; an XY pairing causes it to develop into a male.
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Y chromosome | A type of sex chromosome. An XX mammalian embryo becomes female; an XY pairing causes it to develop into a male. |
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